Osteoarthritis (OA) is one of the most well known issues affecting people as they get older. OA is the degeneration and breakdown of the synovial fluid and cartilage within the joints. When these joint components start to break down it causes bones to rub against each other leading to inflammation. This then restricts movement and is painful when joint movement is no longer smooth and fluid. We've all heard of glucosamine, chondroitin and MSM being used for maintaining healthy cartilage and joints, but there's research supporting the use of SAMe to help promote cartilage production and reduce inflammation and pain.
S-Adenosylmethionine or SAMe in its abbreviated form is an essential molecule produced in the body by converting methionine. Deficiencies in SAMe in joint tissues can cause a loss of the fluidity and gel like nature of cartilage. It is an essential component of cartilage production making it a great form of treatment for osteoarthritis.
According to a 2002 meta-analysis, by Sofken et al. 2002, shows that SAMe when taken in high dosage (1200mg per day) is just as effective as most Non-steroidal anti-inflammatory's (NSAIDs) but doesn't have all the negative side-effects to the gastric system associated with NSAID usage such as ulcers, bleeding and more commonly diarrhoea and headaches
*Information contained in this article is for educational purposes only, it is not intended to diagnose, treat or cure any condition and should not be used as a replacement for medical advice.
Sofken et al. 2002, Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis, The Journal of Family Practice, vol. 51, no. 5.
Better Health Victoria, 2015, Medications - Non-steroidal Anti-inflammatory Drugs